Publications

2020

Zhang, Z., Barros-Álvarez, X., Gillespie, J. R., Ranade, R. M., Huang, W., Shibata, S., Molasky, N., Faghih, O., Mushtaq, A., Hol, W. G. J., Verlinde, C. L. M., Buckner, F. S., Fan, E. (2020). Structure-based discovery of selective methionyl tRNA synthetase inhibitors with potent activity against Trypanosoma brucei. RSC Medicinal Chemistry. (11):885-895. Featured on journal’s cover.

2018

Barros-Álvarez, X., Turley, S., Ranade, R. M., Gillespie, J. R., Duster, N. A., Verlinde, C. L. M., Fan, E., Buckner, F. S. Hol, W. G. J. (2018). The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate. Acta Crystallographica Section F, 74: 245-254. doi: 10.1107/S2053230X18003151.

2017

Faghih, O., Zhang, Z., Ranade, R. M., Gillespie, J. R., Creason, S., Huang, W., Shibata, S., Barros-Álvarez, X., Verlinde, C. L. M., Hol, W. G. J., Fan, E., Buckner, F. S. (2017). Development of methionyl-tRNA synthetase inhibitors as antibiotics for Gram-positive bacterial infections. Antimicrobial Agents and Chemotherapy, 61(11). doi: 10.1128/AAC.00999-17. 

Barros-Álvarez, X., Kerchner, K. M., Koh, C. Y., Turley, S., Pardon, E., Steyaert, J., Ranade, R. M., Gillespie, J. R., Zhang, Z., Verlinde, C. L. M., Buckner, F. S., Fan, E., Hol, W. G. J. (2017). Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. Biochimie, 138: 124-136.

Huang, W., Zhang, Z.,Ranade, R. M., Gillespie, J. R., Barros-Álvarez, X., Creason, S. A., Shibata, S., Verlinde, C. L. M., Hol, W. G. J., Buckner, F. S., Fan, E. (2017). Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors. Bioorganic & Medicinal Chemistry Letters, 27(12): 2702-2707.

Devine, W., Diaz-Gonzalez, R., Ceballos-Perez, G., Rojas-Barros, D., Satoh, T., Ranade, R., Barros-Álvarez, X., Hol, W. G. J., Buckner, F. S., Navarro, M., Pollastri, M. (2017). From cells, to mice, to target: Characterization of NEU-1053 (SB-443342) and its analogs for treatment of human African trypanosomiasis. ACS Infectious Diseases, 2017, 3, 225−236. DOI: DOI: 10.1021/acsinfecdis.6b00202.

2016

Huang, W., Zhang, Z., Barros-Álvarez, X., Koh, C. Y., Ranade, R. M., Gillespie, J. R., Creason, S. A., Shibata, S., Verlinde, C. L. M., Hol, W. G. J., Buckner, F. S., Fan, E. (2016). Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. European Journal of Medicinal Chemistry, 124: 1081-1092.

2015

Barros-Álvarez, X., Cáceres, A., Ruiz, M. T., Michels, P. A. M, Concepción, J. L., Quiñones, W. (2015). The glycosomal-membrane associated phosphoglycerate kinase isoenzyme A plays a role in sustaining the glucose flux in Trypanosoma cruzi epimastigotes. Molecular & Biochemical Parasitology, 200: 5-8.

2014

Barros-Álvarez, X., Cáceres, A., Michels, P. A. M, Concepción, J. L., Quiñones, W. (2014). The phosphoglycerate kinase isoenzymes have distinct roles in the regulation of carbohydrate metabolism in Trypanosoma cruzi. Experimental Parasitology. 143: 39–47.

Barros- Álvarez, X., Gualdrón- López, M., Acosta, H., Cáceres, A. J., Graminha, M. A. S., Michels, P. A. M., Concepción, J. L., Quiñones, W. (2014). Glycosomal Targets for Anti-Trypanosomatid Drug Discovery. Current Medicinal Chemistry, 21: 1679-1706.

2011

Gómez-Arreaza, A., Acosta, H., Barros-Álvarez, X., Concepción, J. L., Albericio, F., Avilán, L. (2011). Leishmania mexicana: LACK (Leishmania homologue of receptors for activated C-kinase) is a plasminogen binding protein. Experimental Parasitology, 127: 752-761.